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3 edition of DNA-ligand interactions found in the catalog.

DNA-ligand interactions

DNA-ligand interactions

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Published by Plenum published in cooperation with NATO Scientific Affairs Division .
Written in English

    Subjects:
  • Deoxyribonucleic acid.

  • Edition Notes

    Statementedited by Wilhelm Guschlbauerand Wolfram Saenger.
    SeriesNATO advanced study institutes series -- v.137.
    ContributionsGuschlbauer, Wilhelm., Saenger, Wolfram., NATO Scientific Affairs Division.
    Classifications
    LC ClassificationsQP624
    The Physical Object
    Paginationix,290p.
    Number of Pages290
    ID Numbers
    Open LibraryOL21250655M
    ISBN 100306426676

    The deoxyribonucleic acid (DNA) is the molecule of life that controls all the chemical changes that take place in cells. The interaction of drugs with DNA is among the most important aspects of biological studies in drug discovery and pharmaceutical development processes. Moreover, the knowledge of specific targets in rational design of chemotherapeutics is a fundamental factor, principally Author: Saad Hmoud Alotaibi, Awad Abdalla Momen. Book Annex Membership Educators Gift Cards Stores & Events Help. Auto Suggestions are available once you type at least 3 letters. Use up arrow (for mozilla firefox browser alt+up arrow) and down arrow (for mozilla firefox browser alt+down arrow) to review and enter to select.

    Protein-ligand docking is a key computational method in the design of starting points for the drug discovery process. Custom solutions Request a quote Book a demo Contact you agree to allow omicX and its partners to use cookies to analyse the site's operation and effectiveness, to display ads tailored to your interests and to provide. Overcoming the problem of fast off-rates necessitate the use of a solubilizing ligand that engages in cooperative binding interactions with SWCNTs. Macromolecules may engage in multivalent interactions, resulting in large binding energies for their complexes. These macromolecules may be either synthetic polymers or by: 2.

    The widespread use of uranium for civilian purposes causes a worldwide concern of its threat to human health due to the long-lived radioactivity of uranium and the high toxicity of uranyl ion (UO22+). Although uranyl–protein/DNA interactions have been known for decades, fewer advances are made in understanding their structural-functional impacts. Instead of focusing only on the Author: Ying-Wu Lin. One of the central problems in the study of the mechanism of DNA-ligand interactions is the existence and nature of sequence specificity with respect to the base pairs of DNA. The presence of such a specificity could be of particular significance because it might possibly mean the involvement of specific genes in the effectiveness of the.


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DNA-ligand interactions Download PDF EPUB FB2

This volume contains the texts of the nineteen lectures presented at the NATO-ASI - FEBS Course on "DNA - ligand interactions: from drugs to proteins." The Advanced Study Institute (ASIl was held from August 30th to September 11th.

in the Abbey of Fontevraud (France). The ASI was attended by. This volume contains the texts of the nineteen lectures presented at the NATO-ASI - FEBS Course on "DNA - ligand interactions: from drugs to proteins." The Advanced Study Institute (ASIl was held from August 30th to September 11th.

in the Abbey of Fontevraud (France).Format: Paperback. This volume contains the texts of the nineteen lectures presented at the NATO-ASI - FEBS Course on "DNA - ligand interactions: from drugs to proteins." The Advanced Study Institute (ASIl was held from August 30th to September 11th.

in the Abbey of Fontevraud (France). Get this from a library. DNA--Ligand Interactions: From Drugs to Proteins. [Wilhelm Guschlbauer; Wolfram Saenger] -- This volume contains the texts of the nineteen lectures presented at the NATO-ASI - FEBS Course on "DNA - ligand interactions: from drugs to.

Additional Physical Format: Online version: Chemistry & physics of DNA-ligand interactions. Schenectady, NY: Adenine Press, © (OCoLC) Chemistry & Physics of DNA-Ligand Interactions Hardcover Editor: Neville R.

Kallenbach ISBN X Editorial Review From Book News, Inc. Directed toward researchers and graduate students interested in the structural dynamics. Absorption Spectroscopy to Probe Ligand Binding.

Cite this entry as: () DNA–Ligand Interactions. In: Roberts G.C.K. (eds) Encyclopedia of Biophysics. In biochemistry and pharmacology, a ligand is a substance that forms a complex with a biomolecule to serve a biological purpose.

In protein-ligand binding, the ligand is usually a molecule which produces a signal by binding to a site on a target binding typically results in a change of conformational isomerism (conformation) of the target protein.

The book fills the void between rigorous theoretical discussions of ligand binding for physical chemists (often beyond the needs of bench experimentalists in the life sciences) and compilations of experimental recipes that offer scant regard for the appropriateness of the protocol for the particular ligand interaction under investigation.

A large number of so-called G-quadruplex ligands, displaying varying degrees of affinity and more importantly selectivity (i.e. the ability to interact only with quadruplex-DNA and not duplex-DNA), have been reported.

Access to efficient and robust in vitro assays is needed to effectively monitor and quantify the G-quadruplex DNA/ ligand Cited by: Contents: DNA-ligand modeling. Let us generate a DNA model with a ligand in the minor groove. DNA. Open the Chain the B-DNA section and enter a DNA sequence.

For instance, enter the classical sequence CGCGAATTCGCG into the lower Sequence window and press the Apply button. A DNA model with a conformation close to the Arnott’s conformation is displayed.

dynamics of DNA and for estimating DNA–ligand binding free energies usher in an era of DNA-targeted computer-aided drug discov ery to combat infectious dise ases and noncommunicable disorders.

Methods for investigating G-quadruplex DNA/ligand interactions. Murat P(1), Singh Y, Defrancq E. Author information: (1)Department of Chemistry, The University of Cambridge, Cambridge CB2 1EW, UK. [email protected] DNA is considered an important target for drug design and by:   Basic Concepts and Thermodynamic Relationships.

A protein–ligand–solvent system is a thermodynamic system composed of the solute (i.e., the protein and ligand molecules) and the solvent (i.e., liquid water and buffer ions).In such a system, there are very complex interactions and heat exchange among these substances; and the relationship between these substances and how heat Cited by: We report on the label- and isotope-free monitoring of DNA interactions with low-molecular-weight ligands.

An optical technique based on interference Cited by: These alternative forms of DNA and RNA have an enormous potential of participating in various cellular processes by recognizing ligands such as proteins, drugs and metal ions in a sequence and structure-specific manner.

Such DNA-ligand interactions prove to be highly beneficial when exploited for therapeutic purposes. Allows creation of binding site and docking. MORDOR is a software which contains all of the tools for virtual screening. The software can perform the main docking using its own energetic and minimization routines, but it is also interfaced with ANTECHAMBER for building ligand databases and CHARMM for some state-of-the-art molecular simulation such as calculating the solvation energy.

Structure-Specific Ligand Recognition of Multistranded DNA Structures Such DNA-ligand interactions prove to be highly beneficial when exploited for therapeutic purposes. This book will be. Li, in Comprehensive Nanoscience and Technology, Ligand Binding Can Influence the Mechanical Stability of Proteins.

Protein–ligand interactions, including protein–protein interactions, are ubiquitous in biology and have a profound influence on the thermodynamic stability of proteins.

This volume contains the texts of the nineteen lectures presented at the NATO-ASI - FEBS Course on DNA - ligand interactions: from drugs to proteins. The Advanced Study Institute (ASIl was held from August 30th to September 11th. in Author: Werner Gans.

DNA-drug binding are direct electrostatic interactions, direct van der Waals/packing interactions, complex hydration/dehydration contributions composed of hydrophobic component, solvation electrostatics, solvation van der Waals, ion effects and entropy terms.

DNA-drug binding may be described in the following manner,File Size: KB. Milankovitch and Climate: Understanding the Response to Astronomical Forcing - Ebook written by A. Berger. Read this book using Google Play Books app on your PC, android, iOS devices.

Download for offline reading, highlight, bookmark or take notes while you read Milankovitch and Climate: Understanding the Response to Astronomical : A. Berger.A supramolecular five-component cascade is presented that enables light-controlled transport of an in situ modified ligand between three host systems based on the different complexation preferences of cyclodextrin, cucurbituril, and double-stranded DNA.

The results point Cited by: